Statements (57)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
enzyme
|
| gptkbp:activities |
dependent on temperature
dependent on membrane potential dependent on pH |
| gptkbp:assemblyLocation |
multiple protein subunits
|
| gptkbp:associatedWith |
diabetes
aging cancer metabolic disorders neurodegenerative diseases cardiovascular diseases mitochondrial diseases |
| gptkbp:clinicalTrials |
biomarker for diseases
target for drug development |
| gptkbp:composedOf |
F0 and F1 subunits
|
| gptkbp:energyEfficiency |
proton gradient
|
| gptkbp:established |
gptkb:Paul_D._Boyer
|
| gptkbp:function |
synthesize_ATP
|
| https://www.w3.org/2000/01/rdf-schema#label |
ATP synthase
|
| gptkbp:inheritsFrom |
conserved across species
|
| gptkbp:involvedIn |
apoptosis
cell differentiation cell growth cell signaling cellular respiration immune response ion transport metabolic pathways muscle contraction neurotransmitter release oxidative phosphorylation photosynthesis substrate-level phosphorylation stress response thermogenesis cellular signaling pathways metabolic adaptation cellular repair mechanisms energy coupling sperm motility |
| gptkbp:isActiveIn |
gptkb:venturicidin
oligomycin |
| gptkbp:locatedIn |
1960s
animals bacteria plants |
| gptkbp:location |
inner mitochondrial membrane
|
| gptkbp:participatesIn |
energy metabolism
ATP_production |
| gptkbp:regulates |
proton motive force
ADP_availability |
| gptkbp:researchFocus |
bioenergetics
mitochondrial function energy transfer mechanisms |
| gptkbp:structureType |
complex enzyme
|
| gptkbp:triggerType |
rotational catalysis
|
| gptkbp:was_a_catalyst_for |
ADP_and_inorganic_phosphate_to_ATP
|