Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
gptkb:SCD1
delta-9 desaturase |
| gptkbp:associatedWith |
gptkb:non-alcoholic_fatty_liver_disease
obesity lipid metabolism insulin resistance |
| gptkbp:catalyzes |
desaturation of stearoyl-CoA to oleoyl-CoA
|
| gptkbp:cofactor |
gptkb:NADH
oxygen cytochrome b5 |
| gptkbp:EC_number |
1.14.19.1
|
| gptkbp:encodedBy |
SCD gene
|
| gptkbp:expressedIn |
gptkb:cancer
brain heart liver adipose tissue |
| gptkbp:foundIn |
gptkb:Mus_musculus
gptkb:Homo_sapiens |
| gptkbp:function |
introduces double bond at delta-9 position of fatty acids
|
| gptkbp:gene |
SCD
|
| https://www.w3.org/2000/01/rdf-schema#label |
Stearoyl-CoA desaturase-1
|
| gptkbp:inhibitedBy |
sterculic acid
|
| gptkbp:involves |
lipogenesis
energy homeostasis biosynthesis of monounsaturated fatty acids |
| gptkbp:locatedIn |
gptkb:endoplasmic_reticulum
|
| gptkbp:locatedOnChromosome |
10q24.31
|
| gptkbp:molecularWeight |
~42 kDa
|
| gptkbp:mutationAssociatedWith |
affects lipid composition
affects metabolic rate |
| gptkbp:orthologIn |
SCD3
SCD4 SCD2 |
| gptkbp:PDB |
4YMK
|
| gptkbp:product |
oleoyl-CoA
|
| gptkbp:regulates |
regulated by insulin
regulated by PPAR-alpha regulated by SREBP-1c regulated by dietary factors regulated by leptin |
| gptkbp:structure |
integral membrane protein
|
| gptkbp:substrate |
stearoyl-CoA
|
| gptkbp:target |
gptkb:cancer
metabolic disease therapy |
| gptkbp:UniProtID |
gptkb:O00767
|
| gptkbp:bfsParent |
gptkb:SCD1
|
| gptkbp:bfsLayer |
7
|