Stearoyl-CoA desaturase-1

URI: https://gptkb.org/entity/Stearoyl-CoA_desaturase-1

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:enzyme
gptkbp:alternativeName	gptkb:SCD1 delta-9 desaturase
gptkbp:associatedWith	gptkb:non-alcoholic_fatty_liver_disease obesity lipid metabolism insulin resistance
gptkbp:catalyzes	desaturation of stearoyl-CoA to oleoyl-CoA
gptkbp:cofactor	gptkb:NADH oxygen cytochrome b5
gptkbp:EC_number	1.14.19.1
gptkbp:encodedBy	SCD gene
gptkbp:expressedIn	gptkb:adipose_tissue gptkb:cancer brain heart liver
gptkbp:foundIn	gptkb:Mus_musculus gptkb:Homo_sapiens
gptkbp:function	introduces double bond at delta-9 position of fatty acids
gptkbp:gene	SCD
gptkbp:inhibitedBy	sterculic acid
gptkbp:involves	lipogenesis energy homeostasis biosynthesis of monounsaturated fatty acids
gptkbp:locatedIn	gptkb:endoplasmic_reticulum
gptkbp:locatedOnChromosome	10q24.31
gptkbp:molecularWeight	~42 kDa
gptkbp:mutationAssociatedWith	affects lipid composition affects metabolic rate
gptkbp:orthologIn	SCD3 SCD4 SCD2
gptkbp:PDB	4YMK
gptkbp:product	oleoyl-CoA
gptkbp:regulates	regulated by insulin regulated by PPAR-alpha regulated by SREBP-1c regulated by dietary factors regulated by leptin
gptkbp:structure	integral membrane protein
gptkbp:substrate	stearoyl-CoA
gptkbp:target	gptkb:cancer metabolic disease therapy
gptkbp:UniProtID	gptkb:O00767
gptkbp:bfsParent	gptkb:SCD1
gptkbp:bfsLayer	8
https://www.w3.org/2000/01/rdf-schema#label	Stearoyl-CoA desaturase-1