|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
Op18
oncoprotein 18
phosphoprotein p19
|
|
gptkbp:alternativeSplicing
|
no known variants
|
|
gptkbp:associatedWith
|
cancer progression
|
|
gptkbp:conservedIn
|
vertebrates
|
|
gptkbp:encodedBy
|
STMN1 gene
|
|
gptkbp:Entrez_Gene_ID
|
3925
ENSG00000104435
|
|
gptkbp:expressed_during
|
cell proliferation
|
|
gptkbp:expressedIn
|
brain
lymphoid tissues
various tumors
|
|
gptkbp:family
|
stathmin family
|
|
gptkbp:firstDescribed
|
1989
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
regulates microtubule dynamics
promotes microtubule depolymerization
|
|
gptkbp:gene
|
gptkb:STMN1
|
|
gptkbp:GO_term
|
GO:0007017 (microtubule-based process)
GO:0008017 (microtubule binding)
|
|
gptkbp:HGNC_ID
|
HGNC:6510
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Stathmin
|
|
gptkbp:inhibitedBy
|
phosphorylation
microtubule polymerization
|
|
gptkbp:interactsWith
|
tubulin
|
|
gptkbp:involves
|
cell cycle regulation
mitosis
|
|
gptkbp:length
|
149 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:1p36.11
|
|
gptkbp:molecularWeight
|
approximately 18 kDa
|
|
gptkbp:OMIM
|
151442
|
|
gptkbp:orthologInMouse
|
Stmn1
|
|
gptkbp:overexpressedIn
|
various cancers
|
|
gptkbp:PDB
|
1SA0
|
|
gptkbp:phosphorylates
|
gptkb:cyclin-dependent_kinases
MAP kinases
|
|
gptkbp:postTranslationalModification
|
phosphorylation
|
|
gptkbp:RefSeq
|
NM_007029
|
|
gptkbp:regulates
|
phosphorylation-dependent
|
|
gptkbp:role
|
neurodegenerative diseases
oncogenesis
|
|
gptkbp:structure
|
contains coiled-coil domain
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
|
|
gptkbp:target
|
microRNAs
|
|
gptkbp:UniProtID
|
P16949
|
|
gptkbp:usedFor
|
proliferation marker
|
|
gptkbp:bfsParent
|
gptkb:Microtubule_Associated_Protein
|
|
gptkbp:bfsLayer
|
6
|