|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
SPAK
STE20/SPS1-related proline-alanine-rich kinase
|
|
gptkbp:associatedWith
|
hypertension
preeclampsia
|
|
gptkbp:biologicalProcess
|
protein serine/threonine kinase activity
cellular response to osmotic stress
regulation of sodium ion transport
|
|
gptkbp:discoveredBy
|
1999
|
|
gptkbp:encodes
|
serine/threonine-protein kinase SPAK
|
|
gptkbp:Entrez_Gene_ID
|
27347
ENSG00000101109
|
|
gptkbp:expressedIn
|
gptkb:kidney
brain
heart
|
|
gptkbp:fullName
|
serine/threonine kinase 39
|
|
gptkbp:function
|
signal transduction
regulation of blood pressure
regulation of ion transport
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
gptkb:STK39
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
STK39 gene
|
|
gptkbp:interactsWith
|
OSR1
WNK1
WNK4
|
|
gptkbp:length
|
545
|
|
gptkbp:locatedOnChromosome
|
chromosome 2
2q24.3
|
|
gptkbp:molecularWeight
|
62 kDa
|
|
gptkbp:OMIM
|
604984
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Stk39
|
|
gptkbp:pathway
|
WNK-SPAK/OSR1 signaling pathway
|
|
gptkbp:phosphorylates
|
gptkb:SLC12A1
gptkb:SLC12A3
SLC12A2
|
|
gptkbp:proteinFamily
|
gptkb:STE20_family
|
|
gptkbp:regulates
|
activated by WNK kinases
inhibited by protein phosphatase 1
|
|
gptkbp:significance
|
potential target for antihypertensive therapy
polymorphisms associated with blood pressure variation
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:Q9UEW8
|
|
gptkbp:bfsParent
|
gptkb:STORK-7
|
|
gptkbp:bfsLayer
|
7
|