Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:associatedWith |
genetic diseases
drug response |
| gptkbp:database |
gptkb:GeneCards
gptkb:NCBI_Gene gptkb:HGNC gptkb:UniProt |
| gptkbp:example |
gptkb:SLC6A4
gptkb:SLC22A1 gptkb:SLC25A1 gptkb:SLC12A3 gptkb:SLC2A1 |
| gptkbp:foundIn |
humans
mammals other eukaryotes |
| gptkbp:fullName |
solute carrier genes
|
| gptkbp:function |
encode membrane transport proteins
mediate transport of ions, metabolites, and drugs |
| https://www.w3.org/2000/01/rdf-schema#label |
SLC genes
|
| gptkbp:mutationAssociatedWith |
can affect drug pharmacokinetics
can cause blood disorders can cause inherited metabolic disorders can cause kidney diseases can cause neurological diseases |
| gptkbp:namingConvention |
SLC followed by a number and letter (e.g., SLC1A1)
|
| gptkbp:notableMember |
gptkb:SLC6A4
gptkb:SLC22A1 gptkb:SLC25A1 gptkb:SLC12A3 gptkb:SLC2A1 |
| gptkbp:numberOfFamilies |
over 65
|
| gptkbp:numberOfGenes |
over 400
|
| gptkbp:publicTransit |
facilitated diffusion
secondary active transport |
| gptkbp:relatedTo |
membrane transport
ABC transporter genes |
| gptkbp:role |
metabolism
neurotransmission renal function drug transport amino acid transport glucose transport ion homeostasis |
| gptkbp:studiedIn |
molecular biology
pharmacogenomics clinical genetics genetic association studies |
| gptkbp:bfsParent |
gptkb:solute_carrier_family
|
| gptkbp:bfsLayer |
6
|