|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:MCT1
monocarboxylate transporter 1
|
|
gptkbp:associatedWith
|
cancer metabolism
exercise-induced hyperinsulinism
|
|
gptkbp:clinicalTrialPhase
|
genetic testing for hyperinsulinism
|
|
gptkbp:component
|
integral component of plasma membrane
|
|
gptkbp:discoveredBy
|
Halestrap AP
|
|
gptkbp:encodes
|
Monocarboxylate transporter 1
|
|
gptkbp:Entrez_Gene_ID
|
6566
ENSG00000141526
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:kidney
brain
heart
liver
|
|
gptkbp:firstDescribed
|
1994
|
|
gptkbp:function
|
proton-linked monocarboxylate transporter
lactate transmembrane transporter activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GOProcess
|
monocarboxylic acid transport
|
|
gptkbp:HGNC_ID
|
10926
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SLC16A1
|
|
gptkbp:inhibitedBy
|
gptkb:phloretin
AR-C155858
alpha-cyano-4-hydroxycinnamate
|
|
gptkbp:length
|
12 exons
500 amino acids
|
|
gptkbp:locatedOnChromosome
|
1p13.2
|
|
gptkbp:memberOf
|
solute carrier family 16
|
|
gptkbp:molecularWeight
|
54 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:congenital_hyperinsulinism
|
|
gptkbp:OMIM
|
600682
|
|
gptkbp:orthologInMouse
|
Slc16a1
|
|
gptkbp:pathway
|
gptkb:pyruvate_metabolism
glycolysis
gluconeogenesis
lactate transport
|
|
gptkbp:proteinFamily
|
gptkb:major_facilitator_superfamily
|
|
gptkbp:regulates
|
gptkb:AMPK
gptkb:hypoxia
HIF-1
|
|
gptkbp:subcellularLocation
|
gptkb:plasma_membrane
|
|
gptkbp:transmembraneDomains
|
12
|
|
gptkbp:transportation
|
gptkb:pyruvate
lactate
ketone bodies
|
|
gptkbp:UniProtID
|
P53985
|
|
gptkbp:bfsParent
|
gptkb:solute_carrier_family
|
|
gptkbp:bfsLayer
|
6
|