Runx1

GPTKB entity

Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:gene
gptkbp:alsoKnownAs gptkb:AML1
gptkb:CBFA2
gptkbp:associatedWith gptkb:acute_myeloid_leukemia
gptkb:familial_platelet_disorder_with_propensity_to_myeloid_malignancy
gptkbp:discoveredBy gptkb:Yoshida_et_al.
gptkbp:domain Runt domain
gptkbp:encodes runt-related transcription factor 1
gptkbp:Entrez_Gene_ID 861
ENSG00000159216
gptkbp:expressedIn hematopoietic stem cells
gptkbp:GO_term gptkb:GO:0008283
GO:0005515
GO:0005634
GO:0003677
GO:0003700
GO:0006355
GO:0006366
GO:0045944
GO:0001227
GO:0001228
GO:0045893
gptkbp:hasTranscriptVariant Runx1a
Runx1b
Runx1c
gptkbp:HGNC_ID 10471
https://www.w3.org/2000/01/rdf-schema#label Runx1
gptkbp:interactsWith gptkb:CBFβ
gptkbp:involvedIn embryonic development
hematopoiesis
lymphocyte development
megakaryocyte differentiation
myeloid cell differentiation
gptkbp:locatedOnChromosome chromosome 21
gptkbp:memberOf gptkb:RUNX_family
gptkbp:mutationAssociatedWith leukemogenesis
gptkbp:OMIM 151385
gptkbp:orthologIn RUNX1 (human)
Runx1 (mouse)
gptkbp:PDB 1H9D
1IO3
1IO4
1LJM
gptkbp:regulates apoptosis
cell differentiation
cell proliferation
transcription of target genes
gptkbp:transcriptionFactorFor gptkb:gene
gptkbp:UniProtID Q01196
gptkbp:bfsParent gptkb:RUNX1
gptkbp:bfsLayer 7