|
gptkbp:instanceOf
|
gptkb:cancer
gptkb:disease
|
|
gptkbp:affects
|
eye
retina
|
|
gptkbp:canBeBilateral
|
true
|
|
gptkbp:canBeFatalIfUntreated
|
true
|
|
gptkbp:canBeSporadic
|
true
|
|
gptkbp:canBeUnilateral
|
true
|
|
gptkbp:canMetastasizeTo
|
brain
lymph nodes
bone marrow
|
|
gptkbp:cause
|
blindness
loss of eye
|
|
gptkbp:causedBy
|
mutation in RB1 gene
|
|
gptkbp:commonIn
|
children
|
|
gptkbp:complication
|
metastasis
secondary cancers in hereditary cases
|
|
gptkbp:detects
|
gptkb:CT_scan
MRI
ultrasound
red reflex test
|
|
gptkbp:diagnosedBy
|
imaging
ophthalmic examination
|
|
gptkbp:eponymOf
|
Flexner-Wintersteiner rosettes
|
|
gptkbp:firstDescribed
|
gptkb:James_Wardrop
|
|
gptkbp:hasGeneticInheritance
|
autosomal dominant
|
|
gptkbp:hasHistopathology
|
Flexner-Wintersteiner rosettes
|
|
gptkbp:hasSurvivalRate
|
over 90% in developed countries
|
|
gptkbp:hasTumorSuppressorGene
|
gptkb:RB1
|
|
gptkbp:hereditary
|
true
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Retinoblastoma
|
|
gptkbp:ICD-10_code
|
C69.2
|
|
gptkbp:incidence
|
1 in 15,000 to 20,000 live births
|
|
gptkbp:MeSH_ID
|
D012177
|
|
gptkbp:OMIM
|
180200
|
|
gptkbp:originatedIn
|
retinal cell
|
|
gptkbp:prognosis
|
good with early treatment
|
|
gptkbp:riskFactor
|
family history
germline RB1 mutation
|
|
gptkbp:stageName
|
gptkb:International_Classification_of_Retinoblastoma
|
|
gptkbp:symptom
|
gptkb:leukocoria
vision loss
strabismus
eye redness
|
|
gptkbp:treatment
|
radiation therapy
chemotherapy
laser therapy
cryotherapy
enucleation
|
|
gptkbp:bfsParent
|
gptkb:cancer_predisposition_syndrome
|
|
gptkbp:bfsLayer
|
6
|