Statements (26)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:physicist
|
| gptkbp:activities |
highly active in rapidly dividing cells
|
| gptkbp:clinical_trial |
implicated in cancer biology
|
| gptkbp:discovered_by |
discovered in the 1960s
|
| gptkbp:established |
gptkb:actinomycin_D
|
| gptkbp:function |
synthesize ribosomal RNA (r RNA)
transcribes r RNA genes |
| gptkbp:genetic_diversity |
can lead to defects in r RNA synthesis
|
| gptkbp:has_member |
largest subunit (A190)
second largest subunit (A135) |
| https://www.w3.org/2000/01/rdf-schema#label |
RNA polymerase I
|
| gptkbp:is_compared_to |
different from RNA polymerase II
different from RNA polymerase III |
| gptkbp:location |
nucleolus
|
| gptkbp:origin |
evolved from a common ancestor with other polymerases
selectivity factor 1 (S L1) upstream binding factor (UBF) |
| gptkbp:products |
pre-r RNA
|
| gptkbp:regulatory_compliance |
controlled by transcription factors
|
| gptkbp:role |
ribosome biogenesis
|
| gptkbp:social_structure |
multi-subunit enzyme
|
| gptkbp:species |
eukaryotes
|
| gptkbp:transcribed_for |
involves specific termination signals
requires promoter sequences |
| gptkbp:bfsParent |
gptkb:RNA_polymerase_II
|
| gptkbp:bfsLayer |
4
|