RNA-directed RNA polymerase

URI: https://gptkb.org/entity/RNA-directed_RNA_polymerase
GPTKB entity
Statements (32)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alternativeName gptkb:RNA_replicase
gptkb:RdRp
gptkbp:catalyzes phosphodiester bond formation
gptkbp:cofactor Mg2+
Mn2+
gptkbp:compatibleWith most prokaryotes
gptkbp:discoveredBy gptkb:A._S._Spirin
gptkbp:discoveredIn 1967
gptkbp:EC_number 2.7.7.48
gptkbp:encodedBy gptkb:virus
host genome (in some eukaryotes)
gptkbp:foundIn viruses
eukaryotes
gptkbp:function synthesizes RNA from RNA template
gptkbp:GO_term GO:0003968
https://www.w3.org/2000/01/rdf-schema#label RNA-directed RNA polymerase
gptkbp:inhibitedBy gptkb:Favipiravir
gptkb:Remdesivir
gptkbp:mechanismOfAction template-dependent polymerization
gptkbp:presentIn gptkb:negative-sense_RNA_viruses
gptkb:positive-sense_RNA_viruses
gptkbp:requires gptkb:RNA_interference
viral genome replication
coronavirus replication
hepatitis C virus replication
influenza virus replication
gptkbp:structure multi-domain protein
gptkbp:target antiviral drugs
gptkbp:UniProtKeyword RNA-directed 5'-3' RNA polymerase activity
gptkbp:bfsParent gptkb:RNA_polymerase
gptkbp:bfsLayer 6