Pyruvate kinase muscle isozyme

URI: https://gptkb.org/entity/Pyruvate_kinase_muscle_isozyme
GPTKB entity
Statements (52)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:activatedBy gptkb:fructose_1,6-bisphosphate
gptkbp:alsoKnownAs gptkb:PKM
gptkbp:alternativeSplicing gptkb:PKM1
gptkb:PKM2
gptkbp:associatedWith cancer metabolism
pyruvate kinase deficiency
gptkbp:catalyzes conversion of phosphoenolpyruvate to pyruvate
gptkbp:cofactor K+
Mg2+
gptkbp:EC_number 2.7.1.40
gptkbp:Entrez_Gene_ID ENSG00000067225
gptkbp:expressedIn gptkb:skeletal_muscle
brain
tumor cells
heart muscle
gptkbp:foundIn gptkb:skeletal_muscle
other tissues
brain tissue
gptkbp:function ATP generation in glycolysis
regulation of metabolic flux
gptkbp:gene gptkb:PKM
gptkb:PKM_gene
gptkbp:HGNC_ID 9021
https://www.w3.org/2000/01/rdf-schema#label Pyruvate kinase muscle isozyme
gptkbp:inhibitedBy alanine
phenylalanine
gptkbp:involvedIn glycolysis
gptkbp:locatedOnChromosome gptkb:chromosome_15
gptkbp:molecularWeight ~58 kDa
gptkbp:mutationAssociatedWith gptkb:cancer
pyruvate kinase deficiency
gptkbp:OMIM 609293
gptkbp:pathway glycolysis
gptkbp:PDB gptkb:1T5A
gptkbp:produces gptkb:ATP
gptkbp:product gptkb:ATP
gptkb:pyruvate
gptkbp:RefSeq NM_002654
gptkbp:regulates allosteric regulation
ATP inhibition
alanine inhibition
fructose 1,6-bisphosphate activation
gptkbp:structure tetramer
gptkbp:substrate phosphoenolpyruvate
gptkbp:subunit gptkb:PKM1
gptkb:PKM2
gptkbp:tissue_specificity high in brain
high in muscle
gptkbp:UniProtID P14618
gptkbp:bfsParent gptkb:PKM
gptkbp:bfsLayer 7