Statements (55)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:drug
antihistamine phenothiazine derivative |
| gptkbp:ATCCode |
R06AD02
|
| gptkbp:brand |
gptkb:Phenergan
gptkb:Promethegan |
| gptkbp:CASNumber |
60-87-7
|
| gptkbp:cause |
photosensitivity
extrapyramidal symptoms (rare) neuroleptic malignant syndrome (rare) |
| gptkbp:contraindication |
children under 2 years
severe respiratory depression hypersensitivity to promethazine |
| gptkbp:discoveredBy |
gptkb:Laboratoires_Rhône-Poulenc
|
| gptkbp:drugClass |
first-generation antihistamine
|
| gptkbp:drugInteraction |
gptkb:beer
gptkb:MAO_inhibitors gptkb:CNS_depressants anticholinergic drugs |
| gptkbp:eliminationHalfLife |
10–19 hours
|
| gptkbp:excretion |
urine
|
| gptkbp:hasMolecularFormula |
C17H20N2S
|
| https://www.w3.org/2000/01/rdf-schema#label |
Promethazine
|
| gptkbp:introducedIn |
1946
|
| gptkbp:legalStatus |
prescription only (US)
prescription only (UK) |
| gptkbp:mechanismOfAction |
sedative
antiemetic H1 receptor antagonist anticholinergic |
| gptkbp:metabolism |
liver
|
| gptkbp:overdoseSymptoms |
seizures
CNS depression cardiac arrhythmias |
| gptkbp:pregnancyCategory |
C (US)
|
| gptkbp:routeOfAdministration |
oral
intramuscular intravenous rectal |
| gptkbp:sideEffect |
constipation
dizziness blurred vision drowsiness dry mouth respiratory depression (rare) |
| gptkbp:usedFor |
nausea
vomiting motion sickness allergy symptoms preoperative sedation insomnia (short-term) cough and cold symptoms |
| gptkbp:bfsParent |
gptkb:Antiemetics
gptkb:Cough_syrup |
| gptkbp:bfsLayer |
6
|