|
gptkbp:instanceOf
|
gptkb:drug
gptkb:antihistamine
gptkb:phenothiazine_derivative
|
|
gptkbp:ATCCode
|
R06AD02
|
|
gptkbp:brand
|
gptkb:Phenergan
gptkb:Promethegan
|
|
gptkbp:CASNumber
|
60-87-7
|
|
gptkbp:cause
|
photosensitivity
extrapyramidal symptoms (rare)
neuroleptic malignant syndrome (rare)
|
|
gptkbp:contraindication
|
children under 2 years
severe respiratory depression
hypersensitivity to promethazine
|
|
gptkbp:discoveredBy
|
gptkb:Laboratoires_Rhône-Poulenc
|
|
gptkbp:drugClass
|
gptkb:first-generation_antihistamine
|
|
gptkbp:drugInteraction
|
gptkb:beer
gptkb:MAO_inhibitors
gptkb:CNS_depressants
anticholinergic drugs
|
|
gptkbp:eliminationHalfLife
|
10–19 hours
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:hasMolecularFormula
|
C17H20N2S
|
|
gptkbp:introducedIn
|
1946
|
|
gptkbp:legalStatus
|
prescription only (US)
prescription only (UK)
|
|
gptkbp:mechanismOfAction
|
gptkb:sedative
gptkb:antiemetic
H1 receptor antagonist
anticholinergic
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:overdoseSymptoms
|
seizures
CNS depression
cardiac arrhythmias
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:routeOfAdministration
|
oral
intramuscular
intravenous
rectal
|
|
gptkbp:sideEffect
|
constipation
dizziness
blurred vision
drowsiness
dry mouth
respiratory depression (rare)
|
|
gptkbp:usedFor
|
nausea
vomiting
motion sickness
allergy symptoms
preoperative sedation
insomnia (short-term)
cough and cold symptoms
|
|
gptkbp:bfsParent
|
gptkb:Antiemetics
gptkb:Cough_Syrup
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Promethazine
|