Progressive supranuclear palsy

GPTKB entity

Predicate	Object
gptkbp:instanceOf	neurodegenerative disease
gptkbp:abbreviation	gptkb:PSP
gptkbp:affects	brain
gptkbp:averageOnsetAge	60s
gptkbp:category	gptkb:tauopathy movement disorder parkinsonism
gptkbp:causedBy	abnormal accumulation of tau protein
gptkbp:characterizedBy	stiffness speech difficulties difficulty with eye movements problems with balance slowed movement swallowing difficulties
gptkbp:diagnosedBy	clinical evaluation MRI
gptkbp:differentialDiagnosis	gptkb:Parkinson's_disease gptkb:corticobasal_degeneration gptkb:multiple_system_atrophy
gptkbp:firstDescribed	gptkb:J.C._Richardson gptkb:Jerzy_Olszewski gptkb:John_Steele 1963
gptkbp:frequency	rare
https://www.w3.org/2000/01/rdf-schema#label	Progressive supranuclear palsy
gptkbp:ICD-10_code	G23.1
gptkbp:MeSH_ID	D020754
gptkbp:namedAfter	supranuclear gaze palsy
gptkbp:OMIM	601104
gptkbp:prevalence	about 6 per 100,000 people
gptkbp:prognosis	poor
gptkbp:progression	gradual
gptkbp:riskFactor	age genetic factors
gptkbp:subspecies	gptkb:PSP-parkinsonism PSP-pure akinesia with gait freezing Richardson syndrome
gptkbp:symptom	rigidity dysphagia frequent falls dysarthria vertical gaze palsy
gptkbp:treatment	supportive care occupational therapy physical therapy speech therapy medications for symptoms
gptkbp:bfsParent	gptkb:Corticobasal_Degeneration
gptkbp:bfsLayer	7