Primary Biliary Cirrhosis

URI: https://gptkb.org/entity/Primary_Biliary_Cirrhosis
GPTKB entity
Statements (34)
Predicate Object
gptkbp:instanceOf gptkb:liver_disease
autoimmune disease
gptkbp:affectsOrgan liver
gptkbp:alsoKnownAs gptkb:Primary_Biliary_Cholangitis
gptkbp:associatedWith gptkb:Sjögren's_syndrome
gptkb:systemic_sclerosis
thyroid disease
other autoimmune diseases
gptkbp:autoantibody antimitochondrial antibody (AMA)
gptkbp:cause cirrhosis
cholestasis
gptkbp:characterizedBy progressive destruction of intrahepatic bile ducts
gptkbp:complication gptkb:bone
hepatocellular carcinoma
portal hypertension
gptkbp:diagnosedBy liver biopsy
antimitochondrial antibodies
elevated alkaline phosphatase
gptkbp:firstDescribed 1851
gptkbp:guidanceSystem gptkb:American_Association_for_the_Study_of_Liver_Diseases_(AASLD)
gptkb:European_Association_for_the_Study_of_the_Liver_(EASL)
https://www.w3.org/2000/01/rdf-schema#label Primary Biliary Cirrhosis
gptkbp:ICD-10_code K74.3
gptkbp:OMIM 109720
gptkbp:prevalence rare
gptkbp:riskFactor age 40-60
female sex
gptkbp:symptom fatigue
jaundice
pruritus
gptkbp:treatment gptkb:ursodeoxycholic_acid
liver transplantation
gptkbp:bfsParent gptkb:Primary_Biliary_Cholangitis
gptkbp:bfsLayer 5