Primary Biliary Cirrhosis

URI: https://gptkb.org/entity/Primary_Biliary_Cirrhosis

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:autoimmune_disease gptkb:liver_disease
gptkbp:affectsOrgan	liver
gptkbp:alsoKnownAs	gptkb:Primary_Biliary_Cholangitis
gptkbp:associatedWith	gptkb:thyroid_disease gptkb:Sjögren's_syndrome gptkb:systemic_sclerosis other autoimmune diseases
gptkbp:autoantibody	antimitochondrial antibody (AMA)
gptkbp:cause	cirrhosis cholestasis
gptkbp:characterizedBy	progressive destruction of intrahepatic bile ducts
gptkbp:complication	gptkb:bone hepatocellular carcinoma portal hypertension
gptkbp:diagnosedBy	liver biopsy antimitochondrial antibodies elevated alkaline phosphatase
gptkbp:firstDescribed	1851
gptkbp:guidanceSystem	gptkb:American_Association_for_the_Study_of_Liver_Diseases_(AASLD) gptkb:European_Association_for_the_Study_of_the_Liver_(EASL)
gptkbp:ICD-10_code	K74.3
gptkbp:OMIM	109720
gptkbp:prevalence	rare
gptkbp:riskFactor	age 40-60 female sex
gptkbp:symptom	fatigue jaundice pruritus
gptkbp:treatment	gptkb:ursodeoxycholic_acid liver transplantation
gptkbp:bfsParent	gptkb:Primary_Biliary_Cholangitis
gptkbp:bfsLayer	5
https://www.w3.org/2000/01/rdf-schema#label	Primary Biliary Cirrhosis