Primary Biliary Cholangitis

GPTKB entity

Statements (36)
Predicate Object
gptkbp:instanceOf gptkb:liver_disease
autoimmune disease
gptkbp:abbreviation gptkb:PBC
gptkbp:affectsOrgan liver
gptkbp:associatedWith anti-mitochondrial antibodies
gptkbp:cause cirrhosis
liver failure
cholestasis
gptkbp:characterizedBy destruction of intrahepatic bile ducts
gptkbp:commonIn gptkb:women
gptkbp:complication gptkb:bone
hepatocellular carcinoma
malabsorption of fat-soluble vitamins
portal hypertension
gptkbp:diagnosedBy liver biopsy
anti-mitochondrial antibody test
liver function tests
gptkbp:firstDescribed 1851
gptkbp:formerName gptkb:Primary_Biliary_Cirrhosis
https://www.w3.org/2000/01/rdf-schema#label Primary Biliary Cholangitis
gptkbp:ICD-10_code K74.3
gptkbp:MeSH_ID D001659
gptkbp:OMIM 109720
gptkbp:prevalence rare
gptkbp:riskFactor family history
other autoimmune diseases
gptkbp:symptom fatigue
jaundice
pruritus
xanthomas
gptkbp:treatment gptkb:obeticholic_acid
gptkb:ursodeoxycholic_acid
liver transplantation
gptkbp:typicalOnsetAge 40-60 years
gptkbp:bfsParent gptkb:PBC
gptkbp:bfsLayer 4