|
gptkbp:instanceOf
|
gptkb:Corticosteroid
|
|
gptkbp:approvedBy
|
1955
|
|
gptkbp:ATCCode
|
gptkb:H02AB07
|
|
gptkbp:bioavailability
|
70-90%
|
|
gptkbp:brand
|
gptkb:Rayos
Deltasone
Sterapred
|
|
gptkbp:canCauseWithdrawalSymptoms
|
true
|
|
gptkbp:CASNumber
|
53-03-2
|
|
gptkbp:chemicalClass
|
synthetic corticosteroid
|
|
gptkbp:contraindication
|
systemic fungal infections
|
|
gptkbp:discoveredBy
|
gptkb:Arthur_Nobile
|
|
gptkbp:eliminationHalfLife
|
2-4 hours
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:hasMolecularFormula
|
C21H26O5
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Prednisone
|
|
gptkbp:isApprovedDrug
|
true
|
|
gptkbp:KEGGID
|
D00447
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
reduces inflammation
suppresses immune response
|
|
gptkbp:MedlinePlusID
|
a601102
|
|
gptkbp:metabolism
|
gptkb:prednisolone
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:proteinBinding
|
70%
|
|
gptkbp:PubChem_CID
|
gptkb:DB00635
5552
5755
CHEMBL1318
|
|
gptkbp:riskOfAdrenalSuppression
|
true
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:shouldBeTapered
|
true
|
|
gptkbp:sideEffect
|
gptkb:bone
high blood pressure
mood changes
weight gain
insomnia
hyperglycemia
increased infection risk
|
|
gptkbp:UNII
|
VB0R961HZT
|
|
gptkbp:usedFor
|
asthma
ulcerative colitis
autoimmune diseases
inflammatory diseases
lupus
rheumatoid arthritis
allergic reactions
organ transplant rejection prevention
multiple sclerosis exacerbations
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
true
included
|
|
gptkbp:bfsParent
|
gptkb:Cortisone
gptkb:Corticosteroid
|
|
gptkbp:bfsLayer
|
6
|