Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
AhpC
TPx alkyl hydroperoxide reductase thioredoxin peroxidase |
| gptkbp:cofactor |
thioredoxin
glutaredoxin |
| gptkbp:discoveredBy |
Dietmar Krause
|
| gptkbp:discoveredIn |
1994
|
| gptkbp:EC_number |
1.11.1.15
|
| gptkbp:enzymeClassification |
oxidoreductase
|
| gptkbp:foundIn |
gptkb:Bacteria
archaea eukaryotes |
| gptkbp:function |
antioxidant enzyme
reduces peroxides |
| gptkbp:GO |
GO:0051920
|
| gptkbp:hasIsoform |
gptkb:PRDX6
PRDX5 PRDX1 PRDX2 PRDX3 PRDX4 |
| https://www.w3.org/2000/01/rdf-schema#label |
Peroxiredoxin
|
| gptkbp:involvedIn |
aging
neurodegenerative diseases cancer progression inflammation regulation redox signaling cellular defense |
| gptkbp:locale |
gptkb:nucleus
gptkb:cytoplasm gptkb:peroxisome mitochondria |
| gptkbp:mechanismOfAction |
catalyzes reduction via cysteine thiol
|
| gptkbp:molecularWeight |
22-28 kDa
|
| gptkbp:PDB |
1QQ2
|
| gptkbp:proteinFamily |
PRDX
|
| gptkbp:regenerates |
glutathione system
thioredoxin system |
| gptkbp:regulates |
histone modification
overoxidation |
| gptkbp:role |
protects against oxidative stress
modulates apoptosis regulates cell signaling |
| gptkbp:structure |
contains cysteine residue
|
| gptkbp:substrate |
gptkb:peroxynitrite
hydrogen peroxide organic hydroperoxides |
| gptkbp:UniProtID |
P0CG48
|
| gptkbp:bfsParent |
gptkb:1R8Q
|
| gptkbp:bfsLayer |
7
|