|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:PLIN
gptkb:perilipin
gptkb:perilipin_1
|
|
gptkbp:associatedWith
|
obesity
lipodystrophy
|
|
gptkbp:discoveredBy
|
gptkb:Greenberg_AS_et_al.
|
|
gptkbp:encodes
|
gptkb:perilipin-1
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000166819
5346
|
|
gptkbp:expressedIn
|
gptkb:brown_adipose_tissue
gptkb:white_adipose_tissue
adipocytes
|
|
gptkbp:firstDescribed
|
1991
|
|
gptkbp:function
|
lipolysis
regulation of lipid storage
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
9072
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PLIN1
|
|
gptkbp:interactsWith
|
gptkb:hormone-sensitive_lipase
gptkb:ABHD5
|
|
gptkbp:length
|
522
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_15
|
|
gptkbp:molecularWeight
|
approximately 57 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:familial_partial_lipodystrophy_type_4
nonsense
missense
frameshift
|
|
gptkbp:OMIM
|
170290
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Plin1
|
|
gptkbp:pathway
|
gptkb:lipolysis_signaling_pathway
lipid metabolism
adipogenesis
|
|
gptkbp:postTranslationalModification
|
phosphorylation
|
|
gptkbp:proteinFamily
|
gptkb:perilipin_family
|
|
gptkbp:regulates
|
gptkb:insulin
gptkb:catecholamines
fasting
feeding
lipid droplet formation
triglyceride hydrolysis
|
|
gptkbp:significance
|
gptkb:type_2_diabetes
gptkb:metabolic_syndrome
insulin resistance
|
|
gptkbp:subcellularLocation
|
lipid droplet membrane
|
|
gptkbp:tissue_specificity
|
adipose tissue
|
|
gptkbp:UniProtID
|
gptkb:O60240
|
|
gptkbp:bfsParent
|
gptkb:familial_partial_lipodystrophy
|
|
gptkbp:bfsLayer
|
7
|