Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
biological pathway
|
| gptkbp:activatedBy |
mitochondrial depolarization
|
| gptkbp:associatedWith |
gptkb:Parkinson's_disease
|
| gptkbp:discoveredIn |
2008
|
| https://www.w3.org/2000/01/rdf-schema#label |
PINK1-Parkin pathway
|
| gptkbp:involvesProtein |
gptkb:PINK1
gptkb:Parkin |
| gptkbp:location |
mitochondria
|
| gptkbp:mutationAssociatedWith |
impaired mitophagy
mitochondrial dysfunction |
| gptkbp:ParkinFunction |
E3 ubiquitin ligase
ubiquitinates mitochondrial proteins |
| gptkbp:ParkinGene |
gptkb:PARK2
|
| gptkbp:ParkinRecruitedBy |
gptkb:PINK1
|
| gptkbp:PINK1AccumulatesOn |
damaged mitochondria
|
| gptkbp:PINK1Function |
phosphorylates ubiquitin
|
| gptkbp:PINK1Gene |
gptkb:PINK1
|
| gptkbp:regulates |
mitochondrial quality control
mitophagy |
| gptkbp:studiedIn |
neurodegeneration
cellular stress response |
| gptkbp:bfsParent |
gptkb:PARK2_gene
|
| gptkbp:bfsLayer |
7
|