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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alternativeName
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PI3-kinase p110-beta subunit
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
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gptkbp:biologicalProcess
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cell survival
signal transduction
cell growth
kinase activity
ATP binding
insulin signaling pathway
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gptkbp:encodedBy
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gptkb:PIK3CB_gene
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gptkbp:enzymeCommissionNumber
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2.7.1.153
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gptkbp:function
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catalyzes phosphorylation of phosphatidylinositol-4,5-bisphosphate
involved in PI3K/AKT signaling pathway
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https://www.w3.org/2000/01/rdf-schema#label
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PIK3CB protein
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gptkbp:interactsWith
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G-protein beta-gamma subunits
PIK3R1 protein
PIK3R2 protein
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gptkbp:length
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1070 amino acids
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gptkbp:locatedOnChromosome
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3q22.3
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gptkbp:location
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gptkb:cytoplasm
gptkb:plasma_membrane
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gptkbp:molecularWeight
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122 kDa
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gptkbp:organism
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gptkb:Homo_sapiens
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gptkbp:orthologIn
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gptkb:Mus_musculus
gptkb:Rattus_norvegicus
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gptkbp:significance
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implicated in cancer
implicated in insulin resistance
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gptkbp:structure
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gptkb:PI3K/PI4K_domain
kinase domain
C2 domain
P85-binding domain
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gptkbp:UniProtID
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gptkb:P42338
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gptkbp:bfsParent
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gptkb:PI3K_beta
gptkb:phosphatidylinositol-4,5-bisphosphate_3-kinase_catalytic_subunit_beta_isoform
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gptkbp:bfsLayer
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6
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