PD-L1 inhibitors

GPTKB entity

Statements (49)
Predicate Object
gptkbp:instanceOf immunotherapy
gptkbp:administeredBy intravenous infusion
gptkbp:approvedBy gptkb:non-small_cell_lung_cancer
gptkb:urothelial_carcinoma
gptkb:triple-negative_breast_cancer
2016
hepatocellular carcinoma
renal cell carcinoma
gptkbp:canBe combination drug
monotherapy
gptkbp:cause hepatitis
inflammatory bowel disease
pneumonitis
endocrinopathies
gptkbp:combines chemotherapy
targeted therapy
other immunotherapies
gptkbp:contraindication severe autoimmune disease
gptkbp:developedBy gptkb:Pfizer
gptkb:AstraZeneca
gptkb:Roche
gptkbp:enhance T-cell immune response
gptkbp:example gptkb:durvalumab
gptkb:atezolizumab
gptkb:avelumab
gptkbp:hasBiomarker gptkb:PD-L1_expression
https://www.w3.org/2000/01/rdf-schema#label PD-L1 inhibitors
gptkbp:inducedBy immune-related toxicity
long-term remission
gptkbp:mechanismOfAction block interaction between PD-L1 and PD-1
prevent tumor immune evasion
gptkbp:monitors clinical assessment
imaging
blood tests
gptkbp:notEffectiveAgainst all cancer types
gptkbp:notRecommendedFor organ transplant recipients
gptkbp:regulates gptkb:FDA
gptkb:EMA
gptkbp:relatedTo gptkb:PD-1_inhibitors
gptkbp:researchArea immunology
oncology
gptkbp:sideEffect diarrhea
fatigue
rash
immune-related adverse events
gptkbp:target PD-L1 protein
gptkbp:usedFor gptkb:cancer
gptkbp:bfsParent gptkb:PD-L1_expression
gptkbp:bfsLayer 6