|
gptkbp:instance_of
|
gptkb:protein
|
|
gptkbp:associated_with
|
low-density lipoprotein (LDL) receptor
|
|
gptkbp:code
|
gptkb:chromosome_1
|
|
gptkbp:discovered_by
|
gptkb:2003
|
|
gptkbp:function
|
regulates cholesterol levels
|
|
gptkbp:has_role
|
cardiovascular diseases
|
|
gptkbp:has_variants
|
that affect cholesterol levels
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PCSK9
|
|
gptkbp:initiated_by
|
monoclonal antibodies
are used to lower cholesterol
|
|
gptkbp:interacts_with
|
LDLR
|
|
gptkbp:involved_in
|
hypercholesterolemia
|
|
gptkbp:is_associated_with
|
atherosclerosis
|
|
gptkbp:is_expressed_in
|
various tissues
macrophages
|
|
gptkbp:is_involved_in
|
lipid metabolism
endocytosis of LDL receptors
|
|
gptkbp:is_linked_to
|
gptkb:familial_hypercholesterolemia
|
|
gptkbp:is_part_of
|
cholesterol homeostasis
|
|
gptkbp:is_regulated_by
|
statins
|
|
gptkbp:is_studied_in
|
clinical trials
|
|
gptkbp:is_targeted_at
|
small interfering RNA (si RNA)
|
|
gptkbp:location
|
liver
|
|
gptkbp:promoter
|
PCSK9 gene
|
|
gptkbp:targets
|
cholesterol-lowering therapies
|
|
gptkbp:bfsParent
|
gptkb:alirocumab
gptkb:evolocumab
|
|
gptkbp:bfsLayer
|
6
|