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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alternativeName
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gptkb:CD3Z
IMD25
CD3-ZETA
T-cell surface antigen CD3 zeta chain
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gptkbp:associatedWith
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Immunodeficiency 25 (IMD25)
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gptkbp:biologicalProcess
|
T cell activation
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gptkbp:cellularComponent
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gptkb:T_cell_receptor_complex
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gptkbp:disulfideBond
|
Yes
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gptkbp:Entrez_Gene_ID
|
919
ENSG00000198851
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gptkbp:expressedIn
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Expressed in T-cells
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gptkbp:function
|
Part of the T-cell receptor-CD3 complex involved in T-cell activation.
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gptkbp:gene
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gptkb:CD247
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gptkbp:goMolecularFunction
|
protein binding
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gptkbp:hasIsoform
|
2
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gptkbp:length
|
164 amino acids
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gptkbp:locatedOnChromosome
|
1
|
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gptkbp:location
|
1q24.2
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gptkbp:molecularWeight
|
18,696 Da
|
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gptkbp:organism
|
gptkb:Homo_sapiens
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gptkbp:orthologIn
|
Cd247 (mouse)
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gptkbp:PDB
|
gptkb:1TGR
|
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gptkbp:postTranslationalModification
|
Phosphorylated on tyrosine residues by LCK upon T-cell activation.
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gptkbp:protein_name
|
gptkb:T-cell_surface_glycoprotein_CD3_zeta_chain
|
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gptkbp:RefSeq
|
NP_000725.1
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gptkbp:reviewedBy
|
Yes (UniProtKB/Swiss-Prot)
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gptkbp:sequenceStatus
|
Complete
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gptkbp:signalPeptide
|
Yes
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gptkbp:subcellularLocation
|
gptkb:Cell_membrane
Single-pass type I membrane protein
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gptkbp:subunit
|
Forms part of the TCR-CD3 complex with CD3G, CD3D, CD3E, and TCR chains.
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gptkbp:transmembraneDomains
|
Yes
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gptkbp:UniProtID
|
gptkb:P20963
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gptkbp:bfsParent
|
gptkb:T-cell_receptor-CD3_complex
|
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gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P20963 (CD247 HUMAN)
|