|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
Alpha-fibrinogen
FGA_HUMAN
Fibrinopeptide A
|
|
gptkbp:associatedWith
|
Congenital afibrinogenemia
Dysfibrinogenemia
|
|
gptkbp:biologicalProcess
|
blood coagulation
|
|
gptkbp:cellularComponent
|
extracellular region
|
|
gptkbp:cleavage
|
Fibrinopeptide A is cleaved by thrombin
|
|
gptkbp:EC_number
|
-
|
|
gptkbp:ensemblId
|
ENSG00000171560
|
|
gptkbp:Entrez_Gene_ID
|
2243
|
|
gptkbp:function
|
Involved in blood clot formation
|
|
gptkbp:gene
|
gptkb:FGA
|
|
gptkbp:goMolecularFunction
|
protein binding
|
|
gptkbp:hasIsoform
|
Alpha-E fibrinogen
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P07327
|
|
gptkbp:interactsWith
|
gptkb:FGB
gptkb:FGG
|
|
gptkbp:lastAnnotationUpdate
|
2021-02-10
|
|
gptkbp:latestReleaseVersion
|
1992-11-01
|
|
gptkbp:locatedOnChromosome
|
4
4q31.3
|
|
gptkbp:location
|
Secreted
|
|
gptkbp:mass
|
95,000 Da
|
|
gptkbp:mutationAssociatedWith
|
Aα Arg16His associated with afibrinogenemia
R35C associated with dysfibrinogenemia
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
Mus musculus Fga
Rattus norvegicus Fga
|
|
gptkbp:pathway
|
Hemostasis
|
|
gptkbp:PDB
|
1FZA
3GHG
1FZB
|
|
gptkbp:postTranslationalModification
|
Disulfide bond
Glycosylation
|
|
gptkbp:protein_name
|
Fibrinogen alpha chain
|
|
gptkbp:proteinFamily
|
Fibrinogen family
|
|
gptkbp:RefSeq
|
NP_000499.1
|
|
gptkbp:reviewedBy
|
Yes
|
|
gptkbp:sequence
|
866
|
|
gptkbp:sequenceStatus
|
Complete
|
|
gptkbp:signalPeptide
|
Yes
|
|
gptkbp:structure
|
Contains coiled coil domain
|
|
gptkbp:subunit
|
Part of fibrinogen complex
|
|
gptkbp:suffersFrom
|
Fibrinogen storage disease
|
|
gptkbp:tissue_specificity
|
Liver
|
|
gptkbp:UniProtID
|
gptkb:P07327
|
|
gptkbp:bfsParent
|
gptkb:HSTD
|
|
gptkbp:bfsLayer
|
7
|