Ornithine aminotransferase

URI: https://gptkb.org/entity/Ornithine_aminotransferase
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alternativeName gptkb:OAT
gptkb:ornithine--oxo-acid_aminotransferase
gptkbp:catalyzes transamination of ornithine to glutamate semialdehyde
gptkbp:cofactor gptkb:pyridoxal_phosphate
gptkbp:deficiencyCauses gptkb:gyrate_atrophy_of_choroid_and_retina
gptkbp:EC_number 2.6.1.13
gptkbp:encodedBy gptkb:OAT_gene
gptkbp:Entrez_Gene_ID GC10P124859
gptkbp:foundIn mitochondria
gptkbp:HGNC_ID 8127
https://www.w3.org/2000/01/rdf-schema#label Ornithine aminotransferase
gptkbp:human_gene_symbol gptkb:OAT
gptkbp:involves glutamate metabolism
proline biosynthesis
ornithine metabolism
gptkbp:locatedOnChromosome gptkb:10q26
gptkbp:molecularWeight ~49 kDa
gptkbp:OMIM 258870
gptkbp:presentIn gptkb:skeletal_muscle
gptkb:kidney
brain
retina
liver
gptkbp:product gptkb:L-glutamate
L-glutamate 5-semialdehyde
gptkbp:RefSeq NM_000274
gptkbp:structure homodimer
gptkbp:substrate gptkb:2-oxoglutarate
gptkb:L-ornithine
gptkbp:UniProtID P04181
gptkbp:bfsParent gptkb:OAT
gptkbp:bfsLayer 7