Statements (26)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
beta-lactamase |
| gptkbp:alternativeName |
oxacillinase
|
| gptkbp:confers_resistance_to |
gptkb:oxacillin
gptkb:cephalosporins penicillins |
| gptkbp:encodedBy |
chromosomal band
plasmid |
| gptkbp:enzymeCommissionNumber |
EC 3.5.2.6
|
| gptkbp:firstDescribed |
1970s
|
| gptkbp:foundIn |
gptkb:Enterobacteriaceae
gptkb:Pseudomonas_aeruginosa gptkb:Acinetobacter_baumannii |
| gptkbp:function |
hydrolyzes beta-lactam antibiotics
|
| gptkbp:gene |
blaOXA
|
| https://www.w3.org/2000/01/rdf-schema#label |
OXA beta-lactamase
|
| gptkbp:inhibitedBy |
clavulanic acid (weakly or not at all)
|
| gptkbp:mechanismOfAction |
hydrolysis of beta-lactam ring
|
| gptkbp:molecularWeight |
~28 kDa
|
| gptkbp:notableVariant |
gptkb:OXA-48
OXA-23 OXA-58 |
| gptkbp:significance |
carbapenem resistance
|
| gptkbp:subclassOf |
class D beta-lactamase
|
| gptkbp:bfsParent |
gptkb:Beta-lactamase
|
| gptkbp:bfsLayer |
7
|