O-6-methylguanine-DNA methyltransferase

URI: https://gptkb.org/entity/O-6-methylguanine-DNA_methyltransferase
GPTKB entity
Statements (32)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:abbreviation gptkb:MGMT
gptkbp:alternativeName gptkb:AGT
O6-alkylguanine-DNA alkyltransferase
O6-methylguanine methyltransferase
gptkbp:associatedWith gptkb:cancer
colorectal cancer
glioma
gptkbp:biologicalProcess alkyl group transfer
gptkbp:EC_number 2.1.1.63
gptkbp:foundIn gptkb:Bacteria
humans
mammals
gptkbp:function DNA repair
gptkbp:gene gptkb:MGMT
https://www.w3.org/2000/01/rdf-schema#label O-6-methylguanine-DNA methyltransferase
gptkbp:inactivation by methylation of promoter
gptkbp:inhibitedBy mutagenesis
cytotoxicity
gptkbp:locatedOnChromosome gptkb:10q26
gptkbp:mechanismOfAction suicide enzyme
gptkbp:PDB 1QNT
gptkbp:regulates epigenetic silencing
gptkbp:removes alkyl groups from O6 position of guanine
gptkbp:significance chemotherapy resistance
glioblastoma treatment
gptkbp:structure single polypeptide chain
gptkbp:substrate O4-methylthymine
O6-methylguanine
gptkbp:UniProtID P16455
gptkbp:bfsParent gptkb:MBGT
gptkbp:bfsLayer 7