Statements (47)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alias |
gptkb:NRP2
PRO2713 VEGF-C receptor VEGF165R2 |
| gptkbp:alternativeSplicing |
produces multiple isoforms
|
| gptkbp:associatedWith |
cancer progression
tumor metastasis lymphatic vessel development |
| gptkbp:encodedBy |
gptkb:NRP2_gene
|
| gptkbp:Entrez_Gene_ID |
ENSG00000099250
8828 |
| gptkbp:expressedIn |
neurons
endothelial cells immune cells lymphatic endothelial cells |
| gptkbp:foundIn |
gptkb:Homo_sapiens
|
| gptkbp:function |
cell surface receptor
co-receptor for VEGF co-receptor for semaphorins |
| gptkbp:gene |
gptkb:NRP2
|
| gptkbp:GO_term |
GO:0016021 (integral component of membrane)
GO:0001525 (angiogenesis) GO:0007155 (cell adhesion) GO:0007411 (axon guidance) |
| gptkbp:HGNC_ID |
HGNC:8006
|
| https://www.w3.org/2000/01/rdf-schema#label |
Neuropilin-2
|
| gptkbp:interactsWith |
gptkb:SEMA3F
gptkb:VEGF-C gptkb:VEGF-D SEMA3B |
| gptkbp:involves |
angiogenesis
axon guidance lymphangiogenesis |
| gptkbp:locatedOnChromosome |
2q34
|
| gptkbp:location |
gptkb:plasma_membrane
|
| gptkbp:molecularWeight |
~103 kDa
|
| gptkbp:OMIM |
601165
|
| gptkbp:orthologInMouse |
Nrp2
|
| gptkbp:PDB |
2ORZ
2QQK |
| gptkbp:structure |
contains coagulation factor V/VIII homology domains
contains CUB domains contains MAM domain |
| gptkbp:UniProtID |
O60462
|
| gptkbp:bfsParent |
gptkb:NRP2
|
| gptkbp:bfsLayer |
6
|