Statements (58)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:drug
nonsteroidal anti-inflammatory drug |
| gptkbp:ATCCode |
M01AE02
|
| gptkbp:availableOn |
gptkb:tablet
suspension suppository |
| gptkbp:brand |
gptkb:Anaprox
gptkb:Naprosyn gptkb:Aleve |
| gptkbp:CASNumber |
22204-53-1
|
| gptkbp:contraindication |
peptic ulcer
hypersensitivity to NSAIDs severe heart failure |
| gptkbp:discoveredBy |
gptkb:Syntex
|
| gptkbp:drugClass |
propionic acid derivative
|
| gptkbp:eliminationHalfLife |
12-17 hours
|
| gptkbp:excretion |
urine
|
| gptkbp:hasMolecularFormula |
C14H14O3
|
| https://www.w3.org/2000/01/rdf-schema#label |
Naproxen
|
| gptkbp:interactsWith |
gptkb:SSRIs
gptkb:aspirin lithium ACE inhibitors diuretics anticoagulants other NSAIDs |
| gptkbp:introducedIn |
1976
|
| gptkbp:IUPACName |
(S)-6-methoxy-α-methyl-2-naphthaleneacetic acid
|
| gptkbp:legalStatus |
over-the-counter
prescription |
| gptkbp:mechanismOfAction |
COX inhibitor
prostaglandin synthesis inhibitor |
| gptkbp:metabolism |
liver
|
| gptkbp:molecularWeight |
230.26 g/mol
|
| gptkbp:pregnancyCategory |
C (first and second trimester)
D (third trimester) |
| gptkbp:prescribes |
osteoarthritis
gout rheumatoid arthritis ankylosing spondylitis tendinitis mild to moderate pain dysmenorrhea bursitis |
| gptkbp:routeOfAdministration |
oral
rectal |
| gptkbp:sideEffect |
nausea
dizziness headache gastrointestinal upset increased risk of bleeding |
| gptkbp:usedFor |
arthritis
pain relief menstrual cramps fever reduction inflammation reduction |
| gptkbp:bfsParent |
gptkb:Zentiva
|
| gptkbp:bfsLayer |
7
|