NADH:ubiquinone oxidoreductase (Complex I)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:enzyme
gptkbp:alsoKnownAs	gptkb:Complex_I NADH dehydrogenase (ubiquinone)
gptkbp:cofactor	gptkb:FMN iron-sulfur clusters
gptkbp:component	electron transport chain
gptkbp:discoveredBy	Ernst Stäcker
gptkbp:discoveredIn	1961
gptkbp:EC_number	1.6.5.3
gptkbp:foundIn	eukaryotes some bacteria
gptkbp:function	catalyzes electron transfer from NADH to ubiquinone pumps protons across mitochondrial inner membrane
gptkbp:gene	gptkb:NDUFA9 gptkb:MT-ND3 gptkb:MT-ND4 gptkb:MT-ND4L gptkb:MT-ND5 gptkb:MT-ND6 gptkb:NDUFS1 gptkb:NDUFS2 gptkb:NDUFS3 gptkb:NDUFS4 gptkb:NDUFS7 gptkb:NDUFS8 gptkb:NDUFV1 gptkb:NDUFV2 gptkb:NDUFV3 gptkb:MT-ND1 gptkb:MT-ND2 NDUFB2 NDUFB5 NDUFA1 NDUFA10 NDUFA11 NDUFA12 NDUFA13 NDUFA2 NDUFA3 NDUFA4 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFAF1 NDUFAF2 NDUFB1 NDUFB10 NDUFB11 NDUFB12 NDUFB13 NDUFB14 NDUFB3 NDUFB4 NDUFB6 NDUFB7 NDUFB8 NDUFB9 NDUFC1 NDUFC2 NDUFS5 NDUFS6
https://www.w3.org/2000/01/rdf-schema#label	NADH:ubiquinone oxidoreductase (Complex I)
gptkbp:inhibitedBy	gptkb:piericidin_A gptkb:rotenone amytal
gptkbp:locatedIn	mitochondrial inner membrane
gptkbp:molecularWeight	~980 kDa (human)
gptkbp:mutationAssociatedWith	gptkb:Parkinson's_disease gptkb:Leigh_syndrome mitochondrial complex I deficiency
gptkbp:product	gptkb:ubiquinol NAD+ protons (H+)
gptkbp:structure	L-shaped
gptkbp:substrate	gptkb:NADH ubiquinone
gptkbp:subunitCount	at least 45
gptkbp:bfsParent	gptkb:NDUFS7
gptkbp:bfsLayer	7