Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:disease
hematologic disorder |
| gptkbp:abbreviation |
gptkb:MDS
|
| gptkbp:affects |
blood
bone marrow |
| gptkbp:can_be_secondary_to |
radiation therapy
chemotherapy congenital syndromes benzene exposure |
| gptkbp:can_progress_to |
gptkb:acute_myeloid_leukemia
|
| gptkbp:cause |
cytopenia
ineffective hematopoiesis |
| gptkbp:diagnosedBy |
blood test
bone marrow biopsy |
| gptkbp:eponymOf |
preleukemia
|
| gptkbp:firstDescribed |
1976
|
| gptkbp:has_cell_type |
dysplastic erythrocytes
dysplastic granulocytes dysplastic megakaryocytes |
| gptkbp:has_genetic_abnormality |
gptkb:TP53_mutation
chromosome 5q deletion chromosome 7q deletion trisomy 8 |
| https://www.w3.org/2000/01/rdf-schema#label |
Myelodysplastic syndrome
|
| gptkbp:ICD-10_code |
D46
|
| gptkbp:marking |
blasts in bone marrow
dysplasia in at least one cell line ring sideroblasts |
| gptkbp:prognosis |
variable
|
| gptkbp:prognostic_scoring_system |
IPSS
IPSS-R |
| gptkbp:riskFactor |
radiation exposure
genetic predisposition older age previous chemotherapy |
| gptkbp:subspecies |
5q- syndrome
refractory anemia refractory anemia with excess blasts refractory cytopenia with multilineage dysplasia |
| gptkbp:symptom |
gptkb:anemia
fatigue infections easy bruising |
| gptkbp:treatment |
supportive care
chemotherapy blood transfusion growth factors stem cell transplantation |
| gptkbp:bfsParent |
gptkb:MDS
|
| gptkbp:bfsLayer |
6
|