|
gptkbp:instanceOf
|
gptkb:disease
|
|
gptkbp:affects
|
lower motor neurons
motor neurons
upper motor neurons
|
|
gptkbp:alsoKnownAs
|
gptkb:ALS
gptkb:Amyotrophic_Lateral_Sclerosis
|
|
gptkbp:averageSurvival
|
2-5 years
|
|
gptkbp:casualties
|
yes
|
|
gptkbp:cause
|
difficulty breathing
difficulty speaking
difficulty swallowing
muscle weakness
muscle wasting
|
|
gptkbp:diagnosedBy
|
gptkb:EMG
neurological examination
MRI
|
|
gptkbp:field
|
neurology
|
|
gptkbp:firstDescribed
|
gptkb:Jean-Martin_Charcot
1869
|
|
gptkbp:gender
|
more common in men
|
|
gptkbp:geneticStudies
|
C9orf72 mutation
FUS mutation
SOD1 mutation
TARDBP mutation
|
|
gptkbp:hasNoCure
|
true
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Motor Neurone Disease
|
|
gptkbp:ICD-10_code
|
G12.2
|
|
gptkbp:incidence
|
1-2 per 100,000 per year
|
|
gptkbp:notableCase
|
gptkb:Stephen_Hawking
gptkb:Lou_Gehrig
|
|
gptkbp:onset
|
adult
|
|
gptkbp:prevalence
|
rare
|
|
gptkbp:prognosis
|
poor
|
|
gptkbp:progression
|
progressive
|
|
gptkbp:relatedTo
|
gptkb:Primary_Lateral_Sclerosis
Progressive Bulbar Palsy
Progressive Muscular Atrophy
Pseudobulbar Palsy
|
|
gptkbp:riskFactor
|
age
family history
genetic mutations
|
|
gptkbp:symptom
|
respiratory failure
weight loss
spasticity
muscle cramps
fasciculations
|
|
gptkbp:treatment
|
gptkb:edaravone
gptkb:riluzole
supportive care
|
|
gptkbp:bfsParent
|
gptkb:Scottish_Motor_Neurone_Disease_Association
|
|
gptkbp:bfsLayer
|
7
|