Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
gptkb:Mitofusin-2
HS protein Hyperplasia suppressor gene protein Transmembrane GTPase MFN2 |
| gptkbp:associatedWith |
gptkb:Charcot-Marie-Tooth_disease_type_2A
|
| gptkbp:biologicalProcess |
cell differentiation
cell proliferation cell death energy homeostasis |
| gptkbp:discoveredBy |
2001
|
| gptkbp:Entrez_Gene_ID |
ENSG00000118579
|
| gptkbp:expressedIn |
gptkb:skeletal_muscle
gptkb:nervous_system heart liver |
| gptkbp:function |
mitochondrial transport
mitochondrial fusion regulation of mitochondrial morphology mitochondrial tethering |
| gptkbp:gene |
gptkb:MFN2
|
| https://www.w3.org/2000/01/rdf-schema#label |
Mitofusin 2
|
| gptkbp:interactsWith |
gptkb:OPA1
Mitofusin 1 |
| gptkbp:locatedIn |
outer mitochondrial membrane
|
| gptkbp:locatedOnChromosome |
gptkb:1p36.22
|
| gptkbp:molecularWeight |
86 kDa
|
| gptkbp:mutationAssociatedWith |
peripheral neuropathy
axonal degeneration |
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
gptkb:Mfn2
|
| gptkbp:orthologInZebrafish |
mfn2
|
| gptkbp:pathway |
mitochondrial dynamics
mitophagy pathway apoptosis pathway |
| gptkbp:PDB |
6JFK
|
| gptkbp:postTranslationalModification |
phosphorylation
sumoylation ubiquitination |
| gptkbp:RefSeq |
NM_014874
|
| gptkbp:regulates |
apoptosis
mitophagy mitochondrial metabolism endoplasmic reticulum-mitochondria tethering mitochondrial network architecture |
| gptkbp:structure |
GTPase domain
coiled-coil domain |
| gptkbp:UniProtID |
O95140
|
| gptkbp:bfsParent |
gptkb:MFN2
|
| gptkbp:bfsLayer |
7
|