Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
gptkb:CMT2A
gptkb:Mitofusin_2 Fzo homolog Fzo2 Ras homolog gene family member V |
| gptkbp:associatedWith |
gptkb:Charcot-Marie-Tooth_disease_type_2A
|
| gptkbp:discoveredIn |
2001
|
| gptkbp:encodedBy |
MFN2 gene
|
| gptkbp:fullName |
gptkb:Mitofusin-2
|
| gptkbp:function |
mitochondrial fusion
regulation of mitochondrial morphology mitochondria-ER tethering mitochondrial tethering |
| gptkbp:gene |
gptkb:MFN2
|
| https://www.w3.org/2000/01/rdf-schema#label |
Mfn2
|
| gptkbp:interactsWith |
gptkb:Mfn1
gptkb:OPA1 |
| gptkbp:involvedIn |
lipid metabolism
neurodegeneration neuronal development tumor suppression insulin signaling mitophagy muscle development response to oxidative stress cardiac function cellular energy homeostasis vascular smooth muscle cell proliferation mitochondria-ER contact sites mitochondrial fusion-fission balance mitochondrial network maintenance |
| gptkbp:locatedIn |
outer mitochondrial membrane
|
| gptkbp:locatedOnChromosome |
gptkb:1p36.22
|
| gptkbp:molecularWeight |
86 kDa
|
| gptkbp:mutationAssociatedWith |
peripheral neuropathy
mitochondrial dysfunction |
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologIn |
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster |
| gptkbp:regulates |
apoptosis
cell proliferation mitochondrial quality control mitochondrial metabolism mitochondrial trafficking |
| gptkbp:structure |
GTPase domain
coiled-coil domain |
| gptkbp:UniProtID |
O95140
|
| gptkbp:bfsParent |
gptkb:Dynamin_family
gptkb:MFN2 |
| gptkbp:bfsLayer |
7
|