|
gptkbp:instanceOf
|
gptkb:antibiotic
antiprotozoal medication
|
|
gptkbp:approvedInUS
|
1963
|
|
gptkbp:ATCCode
|
J01XD01
|
|
gptkbp:brand
|
Flagyl
Metrogel
Noritate
Rozex
|
|
gptkbp:CASNumber
|
443-48-1
|
|
gptkbp:chemicalFormula
|
C6H9N3O3
|
|
gptkbp:contraindication
|
alcohol consumption
hypersensitivity to metronidazole
|
|
gptkbp:discoveredBy
|
gptkb:Rhône-Poulenc
|
|
gptkbp:discoveredIn
|
1955
|
|
gptkbp:drugInteraction
|
gptkb:phenytoin
gptkb:warfarin
gptkb:disulfiram
lithium
phenobarbital
|
|
gptkbp:eliminationHalfLife
|
8 hours
|
|
gptkbp:excretion
|
urine
feces
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Metronidazole
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
disrupts DNA synthesis in microorganisms
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
171.15 g/mol
|
|
gptkbp:pregnancyCategory
|
gptkb:B2
B (US)
|
|
gptkbp:routeOfAdministration
|
oral
topical
vaginal
intravenous
|
|
gptkbp:sideEffect
|
nausea
diarrhea
dizziness
headache
peripheral neuropathy
rash
metallic taste
|
|
gptkbp:spectrumOfActivity
|
gptkb:Amoebozoa
anaerobic bacteria
|
|
gptkbp:usedFor
|
gptkb:Clostridioides_difficile_infection
amebiasis
giardiasis
pelvic inflammatory disease
trichomoniasis
bacterial infections
dental infections
intra-abdominal infections
bacterial vaginosis
protozoal infections
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
included
|
|
gptkbp:bfsParent
|
gptkb:Trichomoniasis
|
|
gptkbp:bfsLayer
|
5
|