Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
Mre11-Rad50-Nbs1 complex
|
| gptkbp:associatedWith |
gptkb:NBN
gptkb:RAD50 MRE11A |
| gptkbp:component |
Mre11
Nbs1 Rad50 |
| gptkbp:discoveredIn |
eukaryotes
|
| gptkbp:function |
DNA damage response
homologous recombination DNA double-strand break repair telomere maintenance activation of ATM kinase |
| gptkbp:homologInProkaryotes |
MR complex (Mre11-Rad50)
|
| https://www.w3.org/2000/01/rdf-schema#label |
MRN complex (eukaryotes)
|
| gptkbp:interactsWith |
gptkb:ATM_kinase
gptkb:CtIP gptkb:BRCA1 DNA ends |
| gptkbp:locale |
gptkb:nucleus
|
| gptkbp:mutationAssociatedWith |
genomic instability
cancer predisposition Nijmegen breakage syndrome |
| gptkbp:regulates |
cell cycle checkpoints
|
| gptkbp:requires |
cell viability
|
| gptkbp:structure |
heterotrimeric
|
| gptkbp:bfsParent |
gptkb:SBC_protein
|
| gptkbp:bfsLayer |
7
|