Statements (62)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:pharmaceuticals
|
| gptkbp:approves |
gptkb:2009
gptkb:FDA |
| gptkbp:availability |
commercially available
|
| gptkbp:class |
hormonal therapy
|
| gptkbp:clinical_trial |
Phase 3
effective in reducing premature puberty well-tolerated in children |
| gptkbp:clinical_use |
pediatric endocrinology
|
| gptkbp:competitors |
competes with other Gn RH agonists
|
| gptkbp:contraindication |
pregnancy
breastfeeding hypersensitivity to leuprolide |
| gptkbp:dosage_form |
depot injection
|
| gptkbp:drug_interactions |
anticoagulants
antidiabetic medications other Gn RH analogs |
| gptkbp:duration |
monthly administration
|
| gptkbp:feedback |
generally positive
some report side effects |
| gptkbp:financial_support |
available through manufacturer
|
| gptkbp:formulation |
sustained-release
injectable suspension |
| https://www.w3.org/2000/01/rdf-schema#label |
Lupron Depot-PED
|
| gptkbp:indication |
delaying puberty
|
| gptkbp:ingredients |
gptkb:leuprolide_acetate
|
| gptkbp:is_monitored_by |
growth rate
bone density hormone levels |
| gptkbp:manufacturer |
gptkb:Abb_Vie
|
| gptkbp:marketed_as |
Lupron Depot for Pediatric Patients
|
| gptkbp:mechanism_of_action |
Gn RH agonist
|
| gptkbp:packaging |
single-dose vial
|
| gptkbp:patient_education |
potential side effects
injection technique importance of follow-up visits |
| gptkbp:patient_population |
gptkb:children
|
| gptkbp:pharmacokinetics |
long half-life
suppresses gonadotropin release |
| gptkbp:price |
varies by insurance
|
| gptkbp:provides_guidance_on |
recommended for CPP
|
| gptkbp:regulatory_compliance |
prescription only
|
| gptkbp:related_products |
gptkb:Lupron
gptkb:Eligard Viadur |
| gptkbp:research |
ongoing studies on long-term effects
|
| gptkbp:route_of_administration |
intramuscular injection
|
| gptkbp:side_effect |
gptkb:anemia
gptkb:depression fatigue nausea weight gain headaches injection site reactions osteoporosis mood changes hot flashes |
| gptkbp:storage |
store at room temperature
|
| gptkbp:type_of_care |
important for efficacy
|
| gptkbp:used_for |
treatment of central precocious puberty
|
| gptkbp:bfsParent |
gptkb:Lupron
|
| gptkbp:bfsLayer |
6
|