Lisinopril

GPTKB entity

Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:drug
ACE inhibitor
gptkbp:approvalYear 1987
gptkbp:approvedBy gptkb:FDA
gptkbp:ATCCode C09AA03
gptkbp:bioavailability 25%
gptkbp:brand Prinivil
Zestril
gptkbp:CASNumber 83915-83-7
gptkbp:category gptkb:World_Health_Organization_essential_medicines
ACE inhibitors
gptkbp:chemicalFormula C21H31N3O5
gptkbp:contraindication pregnancy
bilateral renal artery stenosis
history of angioedema
gptkbp:discoveredBy gptkb:Merck_&_Co.
gptkbp:drugClass ACE inhibitor
antihypertensive
gptkbp:eliminationHalfLife 12 hours
gptkbp:excretion renal
gptkbp:firstPassMetabolism no
gptkbp:genericAvailable yes
https://www.w3.org/2000/01/rdf-schema#label Lisinopril
gptkbp:interactsWith gptkb:insulin
gptkb:NSAIDs
gptkb:aliskiren
lithium
diuretics
potassium-sparing diuretics
antidiabetic drugs
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction inhibits angiotensin-converting enzyme
gptkbp:metabolism not metabolized
gptkbp:molecularWeight 405.5 g/mol
gptkbp:patentExpired yes
gptkbp:pregnancyCategory D (US)
gptkbp:proteinBinding 0%
gptkbp:routeOfAdministration oral
gptkbp:sideEffect dizziness
cough
hypotension
hyperkalemia
angioedema
gptkbp:usedFor heart failure
hypertension
diabetic nephropathy
post-myocardial infarction
gptkbp:WHOModelListOfEssentialMedicines yes
gptkbp:bfsParent gptkb:Zentiva
gptkbp:bfsLayer 7