|
gptkbp:instanceOf
|
gptkb:drug
statin
|
|
gptkbp:annualSalesPeak
|
$12.9 billion (2006)
|
|
gptkbp:approvedBy
|
gptkb:FDA
1996
|
|
gptkbp:ATCCode
|
gptkb:C10AA05
|
|
gptkbp:brand
|
gptkb:atorvastatin
|
|
gptkbp:CASNumber
|
134523-00-5
|
|
gptkbp:chemicalFormula
|
C33H35FN2O5
|
|
gptkbp:color
|
white
|
|
gptkbp:contraindication
|
gptkb:liver_disease
pregnancy
breastfeeding
|
|
gptkbp:discoveredBy
|
gptkb:Bruce_Roth
|
|
gptkbp:eliminationHalfLife
|
14 hours
|
|
gptkbp:form
|
gptkb:tablet
10 mg
20 mg
40 mg
80 mg
|
|
gptkbp:genericAvailable
|
yes
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Lipitor
|
|
gptkbp:indication
|
gptkb:familial_hypercholesterolemia
dyslipidemia
prevention of cardiovascular disease
|
|
gptkbp:interactsWith
|
gptkb:milk
gptkb:cyclosporine
gptkb:warfarin
gptkb:clarithromycin
protease inhibitors
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:manufacturer
|
gptkb:Pfizer
|
|
gptkbp:marketedIn
|
gptkb:Europe
gptkb:Japan
gptkb:United_States
|
|
gptkbp:mechanismOfAction
|
HMG-CoA reductase inhibitor
|
|
gptkbp:metabolism
|
gptkb:CYP3A4
|
|
gptkbp:mostPrescribedStatin
|
yes
|
|
gptkbp:patentExpired
|
2011
|
|
gptkbp:pregnancyCategory
|
gptkb:X_(US)
|
|
gptkbp:prescriptionRequired
|
yes
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
muscle pain
digestive problems
liver enzyme abnormalities
|
|
gptkbp:storage
|
20-25°C (68-77°F)
|
|
gptkbp:usedFor
|
lowering cholesterol
reducing risk of heart attack
reducing risk of stroke
|
|
gptkbp:bfsParent
|
gptkb:Pfizer
|
|
gptkbp:bfsLayer
|
4
|