|
gptkbp:instanceOf
|
gptkb:drug
synthetic thyroid hormone
|
|
gptkbp:ATCCode
|
H03AA01
|
|
gptkbp:bioavailability
|
40-80%
|
|
gptkbp:brand
|
gptkb:Levoxyl
gptkb:Eltroxin
gptkb:Euthyrox
gptkb:Synthroid
Thyroxine
|
|
gptkbp:CASNumber
|
51-48-9
|
|
gptkbp:chemicalFormula
|
C15H11I4NO4
|
|
gptkbp:contraindication
|
gptkb:thyrotoxicosis
untreated adrenal insufficiency
|
|
gptkbp:discoveredBy
|
gptkb:Charles_Robert_Harington
|
|
gptkbp:discoveredIn
|
1926
|
|
gptkbp:eliminationHalfLife
|
about 7 days
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Levothyroxine
|
|
gptkbp:interactsWith
|
gptkb:warfarin
gptkb:cholestyramine
iron supplements
calcium supplements
antacids
|
|
gptkbp:isomerOf
|
gptkb:liothyronine
|
|
gptkbp:KEGGID
|
D08137
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:marketedAs
|
1955
|
|
gptkbp:MedlinePlusID
|
a682461
|
|
gptkbp:MeSH_ID
|
D008131
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
776.87 g/mol
|
|
gptkbp:pregnancyCategory
|
C (US)
A (Australia)
|
|
gptkbp:producedBy
|
thyroid gland (naturally as T4)
|
|
gptkbp:proteinBinding
|
99%
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL1547
5819
DB00451
CHEBI:30660
|
|
gptkbp:routeOfAdministration
|
oral
intravenous
|
|
gptkbp:sideEffect
|
anxiety
weight loss
insomnia
palpitations
hyperthyroidism
osteoporosis (long-term use)
|
|
gptkbp:UNII
|
Q51BO43MG7
|
|
gptkbp:usedFor
|
gptkb:cancer
hypothyroidism
goiter
thyroid hormone replacement
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
true
|
|
gptkbp:bfsParent
|
gptkb:Zentiva
|
|
gptkbp:bfsLayer
|
7
|