LINCS L1000 dataset

GPTKB entity

Statements (32)
Predicate Object
gptkbp:instanceOf biological dataset
gptkbp:availableOn gptkb:Gene_Expression_Omnibus_(GEO)
https://clue.io
gptkbp:cellLines various human cell lines
gptkbp:citation Subramanian et al., Cell, 2017
gptkbp:contains gene expression signatures
gptkbp:developedBy gptkb:Broad_Institute
gptkbp:fundedBy gptkb:NIH_Common_Fund
https://www.w3.org/2000/01/rdf-schema#label LINCS L1000 dataset
gptkbp:license open access
gptkbp:measures transcriptional response to perturbagens
gptkbp:numberOfGenesInferred ~12,000 genes
gptkbp:numberOfGenesMeasured 978 landmark genes
gptkbp:partOf gptkb:Library_of_Integrated_Network-based_Cellular_Signatures_(LINCS)
gptkbp:perturbagens biological factors
small molecules
genetic reagents
gptkbp:relatedTo gptkb:NIH_LINCS_program
gptkb:Connectivity_Map_(CMap)
gptkbp:releaseYear 2014
gptkbp:species gptkb:Homo_sapiens
gptkbp:technology Luminex bead-based assay
gptkbp:type gene expression
perturbation signatures
gptkbp:usedFor gene expression profiling
gptkbp:usedIn systems biology
mechanism of action studies
drug repurposing research
toxicogenomics
gptkbp:bfsParent gptkb:CMap_L1000
gptkb:LINCS_project
gptkbp:bfsLayer 5