Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
biological pathway
|
| gptkbp:cholesterolReleasedIn |
gptkb:cytoplasm
|
| gptkbp:discoveredBy |
gptkb:Michael_S._Brown
gptkb:Joseph_L._Goldstein |
| gptkbp:dysfunctionCauses |
gptkb:familial_hypercholesterolemia
|
| gptkbp:function |
cholesterol homeostasis
|
| https://www.w3.org/2000/01/rdf-schema#label |
LDL receptor pathway
|
| gptkbp:involves |
gptkb:lysosome
gptkb:endosome gptkb:LDL_receptor gptkb:low-density_lipoprotein_(LDL) clathrin-mediated endocytosis |
| gptkbp:LDLDegradedIn |
gptkb:lysosome
|
| gptkbp:location |
gptkb:cell_membrane
liver cell |
| gptkbp:mutationAssociatedWith |
LDL receptor gene (LDLR)
|
| gptkbp:receptorBinds |
gptkb:apolipoprotein_B-100
gptkb:apolipoprotein_E |
| gptkbp:receptorRecycled |
cell surface
|
| gptkbp:regulates |
plasma LDL cholesterol levels
|
| gptkbp:target |
statin drugs
|
| gptkbp:bfsParent |
gptkb:LPA_gene
|
| gptkbp:bfsLayer |
6
|