|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:LDL_receptor
gptkb:LDLR
|
|
gptkbp:associatedWith
|
gptkb:familial_hypercholesterolemia
|
|
gptkbp:discoveredBy
|
gptkb:Michael_S._Brown
gptkb:Joseph_L._Goldstein
|
|
gptkbp:encodedBy
|
gptkb:LDLR_gene
|
|
gptkbp:expressedIn
|
gptkb:adrenal_gland
liver
peripheral tissues
|
|
gptkbp:fullName
|
gptkb:Low-density_lipoprotein_receptor
|
|
gptkbp:function
|
mediates endocytosis of cholesterol-rich LDL
regulates plasma cholesterol levels
|
|
gptkbp:gene
|
gptkb:LDLR
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
LDL-R
|
|
gptkbp:ligand
|
gptkb:apolipoprotein_B-100
gptkb:apolipoprotein_E
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_19
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
~160 kDa
|
|
gptkbp:mutationAssociatedWith
|
elevated blood cholesterol
increased risk of atherosclerosis
|
|
gptkbp:OMIM
|
606945
|
|
gptkbp:pathway
|
cholesterol metabolism
lipoprotein uptake
|
|
gptkbp:PDB
|
gptkb:1N7D
|
|
gptkbp:recipient
|
endocytic receptor
|
|
gptkbp:removes
|
LDL particles from blood
|
|
gptkbp:structure
|
transmembrane glycoprotein
|
|
gptkbp:UniProtID
|
gptkb:P01130
|
|
gptkbp:bfsParent
|
gptkb:LDLR
|
|
gptkbp:bfsLayer
|
7
|