Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
mutant protein
|
| gptkbp:aminoAcidChange |
Glycine to Cysteine at position 12
|
| gptkbp:associatedWith |
gptkb:non-small_cell_lung_cancer
colorectal cancer |
| gptkbp:encodedBy |
gptkb:KRAS_gene
|
| gptkbp:foundIn |
gptkb:human
|
| gptkbp:function |
GTPase activity
|
| gptkbp:hasAlteredFunction |
impaired GTP hydrolysis
|
| https://www.w3.org/2000/01/rdf-schema#label |
KRAS G12C mutant protein
|
| gptkbp:involves |
oncogenesis
|
| gptkbp:molecularWeight |
~21 kDa
|
| gptkbp:mutationAssociatedWith |
G12C
glycine to cysteine |
| gptkbp:mutationAtPosition |
12
|
| gptkbp:pathway |
gptkb:PI3K-AKT_signaling_pathway
gptkb:MAPK_signaling_pathway |
| gptkbp:prevalence |
~13% in NSCLC
~3% in colorectal cancer |
| gptkbp:significance |
predictive biomarker for targeted therapy
|
| gptkbp:target |
gptkb:adagrasib
gptkb:sotorasib |
| gptkbp:bfsParent |
gptkb:Lumykras
|
| gptkbp:bfsLayer |
7
|