KLF1 gene

URI: https://gptkb.org/entity/KLF1_gene
GPTKB entity
Statements (52)
Predicate Object
gptkbp:instanceOf gptkb:gene
gptkbp:alsoKnownAs gptkb:EKLF
gptkbp:discoveredBy gptkb:Stuart_H._Orkin
gptkbp:discoveredIn 1993
gptkbp:encodes gptkb:Kruppel-like_factor_1_protein
gptkbp:Entrez_Gene_ID 10661
gptkbp:expressedIn erythroid cells
erythroid differentiation
gptkbp:fullName gptkb:Kruppel-like_factor_1
gptkbp:function transcription factor
regulation of erythroid cell development
gptkbp:HGNC_ID HGNC:6346
https://www.w3.org/2000/01/rdf-schema#label KLF1 gene
gptkbp:importantFor red blood cell maturation
gptkbp:locatedOnChromosome gptkb:chromosome_19
19p13.13
gptkbp:mutationAssociatedWith gptkb:congenital_dyserythropoietic_anemia_type_IV
gptkb:hereditary_persistence_of_fetal_hemoglobin
can cause anemia
can increase fetal hemoglobin levels
gptkbp:OMIM 600599
gptkbp:orthologInMouse gptkb:Klf1
gptkbp:regulates gptkb:Kruppel-like_factors
beta-globin gene expression
erythropoiesis
GATA2 expression
AHSP expression
ALAS2 expression
ANK1 expression
BCL11A expression
CD44 expression
EPB42 expression
FECH expression
GATA1 expression
HBA expression
HBB expression
HBD expression
HBE expression
HBG expression
HMOX2 expression
KLF2 expression
KLF3 expression
PKLR expression
SLC25A37 expression
SLC25A38 expression
SLC4A1 expression
expression of erythroid-specific genes
hemoglobin switching
gptkbp:UniProtID Q13351
gptkbp:zincFingerDomains 3
gptkbp:bfsParent gptkb:EKLF
gptkbp:bfsLayer 7