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REGEN-COV (casirivimab and imdevimab)
URI:
https://gptkb.org/entity/REGEN-COV_(casirivimab_and_imdevimab)
GPTKB entity
Statements (40)
Predicate
Object
gptkbp:instanceOf
gptkb:COVID-19
monoclonal antibody combination
gptkbp:administeredBy
saline solution
gptkbp:approvedBy
gptkb:EMA_(conditional_approval)
gptkb:FDA_(Emergency_Use_Authorization)
2020
gptkbp:ATCCode
gptkb:J06BD08
gptkbp:brand
gptkb:Ronapreve
gptkb:REGEN-COV
gptkbp:CASNumber
2421380-07-0 (casirivimab)
2421380-08-1 (imdevimab)
gptkbp:contraindication
known hypersensitivity to components
gptkbp:developedBy
gptkb:Regeneron_Pharmaceuticals
gptkb:Roche
gptkbp:effect
reduced with Omicron variant
gptkbp:EUARevoked
2022 (in the US)
gptkbp:form
solution for injection
gptkbp:halfLife
~25-30 days
gptkbp:hasComponent
gptkb:casirivimab
gptkb:imdevimab
https://www.w3.org/2000/01/rdf-schema#label
REGEN-COV (casirivimab and imdevimab)
gptkbp:indication
treatment of COVID-19
post-exposure prophylaxis of COVID-19
gptkbp:legalStatus
prescription only
gptkbp:mechanismOfAction
neutralizes SARS-CoV-2 spike protein
gptkbp:monoclonalAntibodyType
gptkb:IgG1
gptkbp:pregnancyCategory
not assigned
gptkbp:routeOfAdministration
subcutaneous
intravenous
gptkbp:sideEffect
nausea
pruritus
rash
allergic reactions
infusion-related reactions
gptkbp:storage
2–8°C
gptkbp:target
gptkb:SARS-CoV-2_spike_protein
gptkbp:usedDuringPandemic
gptkb:COVID-19_pandemic
gptkbp:WHOModelListOfEssentialMedicines
no
gptkbp:bfsParent
gptkb:Regeneron_Pharmaceuticals
gptkbp:bfsLayer
6