Statements (59)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
gptkb:disease
gptkb:systemic_lupus_erythematosus gptkb:multiple_sclerosis dermatitis cardiovascular diseases chronic kidney disease inflammatory diseases type 1 diabetes |
| gptkbp:code |
Interleukin 17 A protein
|
| gptkbp:discovered_by |
1990s
|
| gptkbp:genetic_studies |
autoimmune disorders
|
| gptkbp:has_role |
gptkb:disease
metabolic syndrome fibrosis tumor microenvironment chronic obstructive pulmonary disease allergic responses pathogenesis of psoriasis |
| https://www.w3.org/2000/01/rdf-schema#label |
IL17 A gene
|
| gptkbp:influences |
cell proliferation
cell migration cytokine production T cell differentiation neutrophil recruitment B cell function immune cell signaling |
| gptkbp:interacts_with |
gptkb:IL-17_receptor
|
| gptkbp:involved_in |
immune response
neuroinflammation chronic inflammation tissue repair host defense mechanisms |
| gptkbp:is_expressed_in |
adipose tissue
skin lesions lung tissue T helper cells intestinal mucosa |
| gptkbp:is_linked_to |
gptkb:asthma
gptkb:Crohn's_disease gptkb:rheumatoid_arthritis gptkb:psoriatic_arthritis gptkb:neurodegenerative_diseases chronic pain uveitis |
| gptkbp:is_regulated_by |
cytokines
|
| gptkbp:is_studied_in |
therapeutic interventions
cancer research therapeutic strategies vaccine responses |
| gptkbp:located_in |
gptkb:human_chromosome_6
|
| gptkbp:promoter_region_contains |
specific transcription factors
|
| gptkbp:regulates |
inflammation
T cell activation immune tolerance antimicrobial peptides |
| gptkbp:therapeutic_target_for |
biologics
|
| gptkbp:bfsParent |
gptkb:IL-17_A
|
| gptkbp:bfsLayer |
6
|