Statements (63)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:bfsLayer |
6
|
| gptkbp:bfsParent |
gptkb:Nuclear_factor_kappa-light-chain-enhancer_of_activated_B_cells_(NF-k_B)
|
| gptkbp:affects |
cell proliferation
|
| gptkbp:connects |
gptkb:NF-κ_B_dimers
|
| gptkbp:damage |
proteasome
|
| gptkbp:function |
inhibit NF-κ B activity
|
| gptkbp:has_role |
immune response
|
| https://www.w3.org/2000/01/rdf-schema#label |
Iκ B proteins
|
| gptkbp:includes |
gptkb:Iκ_Bα
gptkb:Iκ_Bβ gptkb:Iκ_Bε |
| gptkbp:influence |
metabolic processes
|
| gptkbp:interacts_with |
transcription factors
other signaling molecules |
| gptkbp:is_affected_by |
environmental factors
oxidative stress |
| gptkbp:is_aimed_at |
therapeutic agents
|
| gptkbp:is_analyzed_in |
gene expression profiling
|
| gptkbp:is_associated_with |
metabolic disorders
chronic diseases cancer progression |
| gptkbp:is_essential_for |
cell differentiation
T cell activation neuroinflammation cell survival immune tolerance immune cell function |
| gptkbp:is_found_in |
cytoplasm
|
| gptkbp:is_influenced_by |
hormonal changes
dietary factors |
| gptkbp:is_involved_in |
apoptosis regulation
cell cycle regulation cell signaling cellular homeostasis autoimmune diseases inflammation stress response fibrosis tumor microenvironment viral infections cellular signaling pathways cellular stress responses |
| gptkbp:is_known_for |
regulate apoptosis
|
| gptkbp:is_linked_to |
metabolic syndrome
cardiovascular diseases chronic inflammation |
| gptkbp:is_part_of |
innate immunity
NF-κ B signaling pathway |
| gptkbp:is_represented_in |
various tissues
|
| gptkbp:is_studied_in |
gptkb:psychologist
molecular biology aging cancer research chronic inflammatory diseases chronic pain. |
| gptkbp:metabolism |
gptkb:IKK_complex
|
| gptkbp:modifications |
ubiquitination
|
| gptkbp:participated_in |
cytokines
|
| gptkbp:recognizes |
Western blotting
|
| gptkbp:regulates |
gene expression
phosphorylation |
| gptkbp:targets |
drug development
|