Hypoxia-inducible factor family
GPTKB entity
Statements (26)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
low oxygen levels
|
| gptkbp:composedOf |
HIF-1
HIF-2 HIF-3 |
| gptkbp:discoveredIn |
1990s
|
| gptkbp:encodedBy |
gptkb:HIF1A_gene
EPAS1 gene HIF3A gene |
| gptkbp:foundIn |
animals
|
| gptkbp:function |
regulation of cellular response to hypoxia
|
| gptkbp:hasRole |
developmental biology
cancer progression ischemic diseases |
| https://www.w3.org/2000/01/rdf-schema#label |
Hypoxia-inducible factor family
|
| gptkbp:inhibitedBy |
normoxia
|
| gptkbp:memberOf |
basic helix-loop-helix transcription factors
|
| gptkbp:regulates |
apoptosis
cell proliferation angiogenesis cellular metabolism erythropoietin gene expression |
| gptkbp:subunit |
alpha subunit
beta subunit |
| gptkbp:bfsParent |
gptkb:HIF_family
|
| gptkbp:bfsLayer |
7
|