Histone-lysine N-methyltransferase SETD2

URI: https://gptkb.org/entity/Histone-lysine_N-methyltransferase_SETD2
GPTKB entity
Statements (38)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:alternativeName HYPB
KMT3A
SET domain containing 2
gptkbp:associatedWith DNA repair
RNA splicing
transcriptional elongation
gptkbp:catalyzes methylation of lysine 36 on histone H3
gptkbp:cellularComponent gptkb:nucleus
gptkbp:discoveredBy researchers studying histone methylation
gptkbp:domain gptkb:WW_domain
AWS domain
SET domain
SRI domain
gptkbp:EC_number 2.1.1.43
gptkbp:encodedBy SETD2 gene
gptkbp:Entrez_Gene_ID 29072
gptkbp:firstDescribed early 2000s
gptkbp:function histone methyltransferase activity
https://www.w3.org/2000/01/rdf-schema#label Histone-lysine N-methyltransferase SETD2
gptkbp:interactsWith gptkb:RNA_polymerase_II
gptkb:hnRNP_L
LEDGF/p75
gptkbp:length 2564 amino acids
gptkbp:locatedOnChromosome 3p21.31
gptkbp:molecularWeight 256 kDa
gptkbp:mutationAssociatedWith clear cell renal cell carcinoma
Luscan-Lumish syndrome
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologIn Set2 (yeast)
gptkbp:PDB 6J9J
gptkbp:postTranslationalModification phosphorylation
ubiquitination
gptkbp:RefSeq NP_001073276.1
gptkbp:UniProtID Q9BYW2
gptkbp:bfsParent gptkb:KMT3B
gptkbp:bfsLayer 7